It is also one of nine constituencies in the Central Scotland electoral region, which elects seven additional members, in addition to nine constituency MSPs, to produce a form of proportional representation for the region as a whole.

The other nine constituencies of the Central Scotland region are: Airdrie and Shotts, Coatbridge and Chryston, Cumbernauld and Kilsyth, East Kilbride, Falkirk East, Falkirk West, Hamilton, Larkhall and Stonehouse and Motherwell and Wishaw.

The Uddingston and Bellshill Holyrood constituency is one of five covering the North Lanarkshire council area, the others being Airdrie and Shotts, Coatbridge and Chryston, Cumbernauld and Kilsyth and Motherwell and Wishaw.

Part of the constituency includes territory within South Lanarkshire; it is one of five covering the South Lanarkshire council area, the others being Hamilton, Larkhall and Stonehouse and East Kilbride which are within the Central Scotland region, Rutherglen within the Glasgow region, and Clydesdale within the South Scotland region.

At the 2011 Scottish Parliament election, the constituency of Uddingston and Bellshill was fought for the first time.