After the peace of Munster in 1648, Uden remained outside the Dutch republic and was a haven of religious tolerance, and Catholics from the nearby towns of Veghel, Nistelrode and Erp were able to build churches at the municipality's boundaries.

After that time Uden's wealth diminished, mainly due to competition from the neighbouring Brabant towns, resulting in immigration to the Midwestern United States.

That region of Wisconsin remains largely populated by descendants of Dutch Catholic immigrants from the Uden area.

The Midwest was selected for its fairly similar landscape, which allowed the East Dutch immigrants, who were primarily farmers, to continue the same agricultural practices in the United States.

In the 1920s people started to cultivate the extensive heathlands in the eastern part of the municipality, called "De Peel".