Some of its best-known products include Dear Abby, Doonesbury, Ziggy, Garfield, Ann Coulter, Richard Roeper and News of the Weird.

[3] Over decades, the syndicate added other well-known comic strips including Ziggy, Cathy, For Better or For Worse, Calvin and Hobbes, The Far Side, FoxTrot, Baldo, The Boondocks, In the Bleachers, Non Sequitur, Stone Soup, Real Life Adventures, Cornered, Liō, Cul De Sac, Thatababy, Wumo, editorial cartoonists and columnists.

[6] Several newspapers have chosen to replace Dilbert with a new comic strip Andrews McMeel syndicates, Crabgrass by Tauhid Bondia which was introduced in 2022.

[9][10] The United Media deal brought over such long-running comic strips as Alley Oop, Marmaduke, Nancy, and Tarzan.

Existing and formerly syndicated comics by Andrews McMeel Syndication include Dilbert (until February 2023), For Better or For Worse, FoxTrot, Calvin and Hobbes, Garfield, The Boondocks, Doonesbury, Cathy, Pooch Cafe, Baldo, What the Duck, Ink Pen, Liō, Cul de Sac, Ziggy, Tom the Dancing Bug, Ozy and Millie, The Far Side and Peanuts (since February 27, 2011) in newspapers, calendars and books.

[13] The introductory line of titles included Teenage Mutant Ninja Turtles, The Five Fists of Science, Godland, PvP and Too Much Coffee Man.