"Ufton" is derived from the Old English Uffa-tūn = "Uffa's farmstead"; the Domesday Book of 1086 records it as Offetune.

Two minor roads link the village with the A4, crossing the canal and the railway line in the valley bottom.

The larger, Tyle Mill Road, passes through part of Sulhamstead and crosses the railway by a bridge.

Excavation of a site at Ufton Green found a number of scattered Mesolithic stone artefacts.

[5] It had its own parish church of St John the Baptist, the ruined west wall of which survives[5][8] and is a scheduled monument.

This is now Ufton Court, a large Elizabethan manor house about 0.6 miles (1 km) southwest of the village.

It has a chancel, north chapel (used as an organ chamber), nave of three bays, west tower with tall octagonal shingled spire, and south porch.

[13] St Peter's has stained glass windows from two London makers: Charles Clutterbuck and Lavers and Barraud.

[15] Some eminent fellows of the college went on to serve as rectors of the parish, including Henry Beeke (1789-1819, botanist and creator of income tax),[16] James Fraser (1860-1870, future Bishop of Manchester),[16] and Thomas Brooking Cornish (1878-1906, former headmaster of the King's School, Macclesfield).

The Berkshire section of the Berks and Hants Railway from Reading to Hungerford was built through the north of the parish and opened in 1847.

Road deaths at the crossing after the major crash in 2004 have followed in 2009, 2010, 2012 and 2014, bringing the total number of fatalities to eleven.