Located near the center of the province, it is bounded by Andong on the north, Cheongsong on the east, Gunwi County on the south, and Sangju and Yecheon on the west.

South Korean national treasure 77, a five-storied stone pagoda, lies in Geumseong-myeon.

[1] Uiseong is home to Gounsa, one of the 24 head temples of the Jogye Order of Korean Buddhism.

Famous people from Uiseong include Yu Sŏngnyong, prime minister and one of the best loyal contributors during the Japanese invasions of Korea (1592–98), and the "Garlic Girls", women's curling silver medalists at the 2018 Winter Olympics.

The county's primary divisions are as follows: Uiseong has a monsoon-influenced humid continental climate (Köppen: Dwa) with cold, dry winters and hot, rainy summers.