The eparchy encompasses parishes in Florida, Georgia, North Carolina, Ohio, western Pennsylvania, Tennessee, and West Virginia.

Ohio became a major site of ethnic Ukrainian and Ruthenian immigration in the 1870s.

By the 1880s, Cleveland and Tremont were sites of major Ukrainian communities.

Parma and other Ohio towns were further populated by Ukrainian diaspora fleeing in the wake of the First World War and subsequent incorporation of Ukraine into the Soviet Union.

[1] Another major wave of Ukrainian immigration to the United States came after President Harry S. Truman signed the Displaced Persons Act in 1948.