[1][2] The station was situated a short distance east of the Merrimack River.

[1] During the 1940s peak of railway travel, passenger service included these named trains:[3][4] It also served trains that in Lowell, Massachusetts connected with the direct New York - Portland, Maine train that bypassed Boston, the State of Maine Express[5][6] The station served local trains to Boston via Methuen and Lawrence, Massachusetts, and trains north through Concord, Laconia and Plymouth to Woodsville.

Additionally, it served east–west trains to Portsmouth on the Atlantic coast.

[1] Yet a train still went through the city to White River Junction, Vermont, where connections could be made to the New Haven Railroad's Montrealer.

[9] Service in Manchester ended in 1967 with the discontinuing of the Boston-Concord train.