Novena is bounded by Toa Payoh to the north, Bukit Timah to the west, Tanglin to the south and Kallang to the east.

The vicinity is named after the Novena prayer devotions to Our Mother of Perpetual Help, originally established by the Redemptorist Order that settled and propagated within the area.

[9][10] The Clinical Sciences Building of the Lee Kong Chian School of Medicine and various leisure and public spaces complete the complex.

[11] A number of private healthcare providers are situated next to Tan Tock Seng Hospital.

Novena has seen major improvements in terms of new shops opening in the area since Square 2 and Velocity commenced business in recent years.

The list is as follows: Novena is accessible by MRT, with buses serving the city, nearest neighbouring estates and is close proximity to the expressway.