[4] The map effectively eradicated the former 3rd district, which had been represented by Democrat Russ Carnahan since 2005, splitting it between the districts represented by Republicans Blaine Luetkemeyer and Todd Akin and Democrat William Lacy Clay, Jr.

[26] Organizations Organizations Emanuel Cleaver Democratic Emanuel Cleaver Democratic Missouri's 5th Congressional district was perhaps the one most complicated by redistricting, and the legal challenges that have ensued.

[29] Democratic incumbent Emanuel Cleaver successfully won re-election.

Sam Graves Republican Sam Graves Republican Due to realignment following the 2010 U.S. census, the district spanned most of the northern portion of the state, from St. Joseph to Kirksville, and also included most of the state's portion of the Kansas City Metropolitan Area north of the Missouri River.

[34] Jo Ann Emerson Republican Jo Ann Emerson Republican Republican Jo Ann Emerson, who had represented Missouri's 8th congressional district since 1996,[35] was challenged by Democratic nominee Jack Rushin and Libertarian nominee Rick Vandeven.