The United States Mission to the UN Agencies in Rome serves as a link between the Rome-based international organizations and the U.S. government.

[4] The mission, like the other two in Rome and other high-profile ambassadorships in Europe, often gets assigned political appointees rather than career foreign service officers.

As a result, deputy chiefs of mission are selected for their ability to bring foreign service expertise.

As an important donor to these international organizations, the Mission advocates the U.S. government's goal of eliminating global hunger, enhancing nutrition, and the use of agriculture as an engine of economic growth.

Formerly, the United States Mission to the UN Agencies in Rome was located in a building on the Piazza del Popolo.