Incumbent Democratic Senator Jeanne Shaheen ran for re-election to a second term in office.

[4] Shaheen defeated Brown by 51.5% to 48.2%, making him the first man to lose two Senate races to women, as he had lost his 2012 reelection bid in Massachusetts to Elizabeth Warren.

[5] Shaheen became the second Democrat from New Hampshire to be reelected to the Senate and the first since Thomas J. McIntyre in 1972.

However, with 57% of the vote in MSNBC was comfortable enough with Shaheen's lead to declare her the victor.

Shaheen won with a 3.3% margin of victory over Brown, securing a majority of the votes cast by over 1%.