Senator Sherrod Brown won re-election to a second term, defeating Republican Josh Mandel, the Ohio State Treasurer.

Congressman (R-OH);[14] Club for Growth;[15] National Rifle Association of America;[16] Tea Party Express;[17] John McCain, U.S.

He was criticized as Ohio Treasurer for not fulfilling his pledge to serve a four-year term and for not attending any of the Board of Deposit monthly meetings.

[32] Mandel's campaign was singled out by the independent fact-checking group Politifact for its "casual relationship with the truth" and its tendency to "double down" after inaccuracies were pointed out.

The fact-checking group wrote: "For all the gifts Mandel has, from his compelling personal narrative as an Iraq war veteran to a well-oiled fundraising machine, whoppers are fast becoming a calling card of his candidacy.

[36] Mandel's campaign was aided by over $1 million spent primarily on attack ads by a 501(c)(4) organization called the Government Integrity Fund.

[37] Brown was endorsed by the Cleveland Plain Dealer,[38] the Columbus Dispatch,[39] the Toledo Blade,[40] the Youngstown Vindicator,[41] The Cincinnati Enquirer,[42] and the Akron Beacon-Journal.