It plans, coordinates, supports, and conducts employment of space operations across the full range of military operations, including security cooperation, in support of the combatant command's objectives.

[9] By May 2022, plans were changed to first establish the USSPACEFORINDOPAC due to China being the pacing threat.

[5][10][11] "We very deliberately chose INDOPACOM first because we want the nation, the Department of Defense, that combatant command, and anyone who might wish us harm in that region to understand that's what we pay attention to every single day," said General David D. Thompson after the command's activation.

[12] On 25 October 2022, Thompson announced that the USSPACEFOR-INDOPAC would be established on 22 November 2022, with Mastalir taking the helm as its first commander.

Admiral John C. Aquilino handed over the unit flag to Mastalir who assumed as the first commander of USSPACEFOR-INDOPAC.