United Therapeutics is co-headquartered in Silver Spring, Maryland and Research Triangle Park, North Carolina, with additional facilities in Magog and Bromont, Quebec; Melbourne and Jacksonville, Florida; Blacksburg, Virginia; and Manchester, New Hampshire.

[6] United Therapeutics was founded in 1996 by Martine Rothblatt,[7][8] an American lawyer, author, and entrepreneur, who created Sirius XM.

[8] In 2011, United Therapeutics acquired Revivicor, a company focused on developing genetic biotechnology platforms to provide alternative tissue sources for treatment.

[12] With the acquisition of Revivicor, United Therapeutics began the xenokidney program to find alternative sources of organs for patients awaiting a kidney transplant.

On January 7, 2022, a porcine heart provided by United Therapeutics' Revivicor subsidiary in conjunction with the University of Maryland Medical Center was used in the first pig-to-human transplant operation.

[18] In December 2023, United Therapeutics Corporation completed the acquisition of Miromatrix Medical Inc., a biotechnology company that specializes in the development of bioengineered organs composed of human cells.

United Therapeutics also markets Adcirca (tadalafil) for the treatment of pulmonary arterial hypertension under a licensing agreement with Eli Lilly and Company.

United Therapeutics is advancing a pipeline of research and development projects that includes new indications, formulations, and delivery devices for its existing products.

[31] Researchers at The University of Alabama at Birmingham used a UKidney xenokidney in a transplant into a brain-dead recipient, observing kidney function over 77 hours.

The facility serves as the company's co-headquarters and is used for commercial manufacturing of active pharmaceutical ingredients and finished dosage form products.

United Therapeutics also owns a 380,000-square-foot combination manufacturing plant and office building in Research Triangle Park, North Carolina.

The facility serves as the company's co-headquarters and is occupied by clinical research and development, commercialization, logistics, manufacturing, and packaging personnel.

[46] In 2019, United Therapeutics received Women in Technology's Corporate Board Award and was named on Triangle Business Journal's "Best Places to Work List" for the sixth consecutive year.

Using extensive solar arrays, heat mediating wells, and other leading-edge design technologies, Unisphere generates more energy on site than it consumes.

[3] As a PBC, United Therapeutics, while creating value for shareholders, must also consider the best interests of those materially affected by the company's conduct and the specific public benefit that it chooses to adopt in its charter.

United Therapeutics public benefit purpose is "to provide a brighter future for patients through (a) the development of novel pharmaceutical therapies; and (b) technologies that expand the availability of transplantable organs.

"[51] Martine Aliana Rothblatt, founder and chairperson[52] of the board of United Therapeutics, graduated from University of California, Los Angeles, with J.D.