"Se erigen los distritos Universitarios de Potosí y Oruro" It began operating from the Free Faculty of Law in 1876, subordinated to Cancelariato of Chuquisaca.

[2] On February 3, 1893, the University Council of Potosi was installed, under the leadership of chancellor and president Dr. Nicanor Careaga.

Officially in October 1937, it recognizes the autonomy to the university district of Potosi, the first Autonomist Rector was Dr. Alberto Saavedra Nogales.

[3] By Act of November 29, 1924 (enacted on December 2, 1924) by the President of the Republic of Bolivia Dr. Bautista Saavedra Mallea, Potosí University bears the name of eminent intellectual born in Potosí, Dr. Tomás Frías Ametller, recognizing their contribution to the organization of the Bolivian University.

The perimeter on which is seated, reaches 80 thousand square meters, is currently running the facility for lithium carbonate production "Technikum", which is dependent of the Tomás Frías Autonomous University and Freiberg University of Mining and Technology.