It was officially founded in 1979 as a split from the University of Oviedo, incorporating various schools and faculties that had previously been dependent on it and had existed in León for varying lengths of time.

In addition to housing the Biological Sciences section, it hosted the Law program, the San Raimundo de Peñafort Academy, and the SEU (Student Union), all affiliated with the University of Oviedo.

The hospital serves areas including Asturias, Cantabria, the Basque Country, and Castile and León, covering a total of 9.5 million livestock heads.

[6] Located in the center of the city of León, the Rectorate occupies the old building that, for decades, housed the Faculty of Veterinary Medicine, the true origin of the University.

The renovated building was inaugurated during a formal academic ceremony attended by nine rectors and regional, provincial, and local authorities on December 18, 1989.

The Student House occupies a significant portion of the former Faculty of Veterinary Medicine building, located in the city center, where the Government Pavilion is also situated.

Students have access to cultural and recreational facilities within this building, including numerous study rooms with extended opening hours until midnight during exam periods.

It also hosts the Ateneo Cultural, which includes the El Albéitar theater, exhibition halls, conference rooms, and workshops.