It offers courses in the cities of Albacete,[5] Ciudad Real,[6] Cuenca,[7] Toledo,[8] Almadén and Talavera de la Reina.

Research is a fundamental pillar of the university, which has 35 research and development centres and institutes, including the Institute for Regional Development, as well as the Science and Technology Park of Castilla-La Mancha.

[9] The campuses operate on a decentralised basis, although the main governing body is located in Ciudad Real, which coordinates the other centres.

The Albacete campus houses Faculties of Medicine, Economic and Business Sciences, Law and Humanities.

Ciudad Real is home to the Faculties of Chemical Sciences, Law and Social Sciences, Arts, the Higher Technical Schools of Civil Engineering, Information Technology, Industrial Engineering; a Technical Institute of Agriculture; the Polytechnic University School of Almadén; a University School of Nursing; a University School of Teacher Training; and the Puertollano Centre for University Studies.