In September 2016, part of it was dismembered for creation of a third, the newly founded Universidade Estadual da Região Tocantina do Maranhão (UEMASUL).

In 1975, FESM incorporated the São Luís School of Veterinary Medicine and, in 1979, the Faculty of Education of Operators.

94,143, of March 25, 1987, as a special regime Autarchy, legal entity of public law, in the multicampi modality.

7,734, dated April 19, 2002, which provided for new changes in the Government's administrative structure, and became part of the State Planning and Management Department.

The courses are free, 100% online, and accessible to everyone without minimum education requirements, allowing students to adapt their study schedule according to their availability.