After the Second World War, the Staatsbauschule und Landeskunstschule was officially reopened on October 3, 1946, in the Auditorium Maximum of Johannes Gutenberg University Mainz as the succession institution of the State Building School and the State School of Arts and Crafts.

At the Mainz University of Applied Sciences a wide variety of study programs is offered, for example in architecture, civil engineering, geospatial and surveying, real estate project management, interior design, communication design, media design, technical building management, and economics (e.g. business management, international business, business law, career Integrating economics, economic computer science).

The libraries provide books, journals, electronic media and videos for the each subject areas taught at the University of Applied Sciences.

The General Students' Committee (German: Allgemeiner Studierendenausschuss) or AStA, is the acting executive board and the external representing agency of the (constituted) student body at the Mainz University of Applied Sciences.

The AStA is separating in following sectors: administration, office, finance, executive board, university policy, international subjects, culture, light and sound, public relation, social matters, sport, traffic and directorate.