Writer and jurist Cino from Pistoia, living in Marche in the years 1319–22, and in Camerino in the spring of 1331, described the territory as teeming with law schools.

[citation needed] Upon the request of Gentile III da Varano, Gregory XI issued the papal edict of 29 January 1367, addressed to the municipality and to the people, authorizing Camerino to confer (after appropriate examination) bachelor and doctoral degrees with apostolic authority, although only in legal studies and only for a limited period.

After Camerino lost its importance as a political centre, the university declined and had vanished by 1600.

[3] In 1723, Benedict XIII founded the Universitas Studii Generalis with the faculties of theology, jurisprudence, medicine, and mathematics.

On 13 April 1756 the validity of the degrees from Camerino was extended to the whole territory of the Holy Roman Empire and the title of palatine count bestowed on the vice-chancellor.