On March 23, 2006, the Florida Board of Governors voted 15–1 in support of UCF's proposal to build a medical college.

The new College of Medicine offered an unprecedented full scholarship package to every member of its charter class; 41 students entering in fall 2009.

[5] UCF's College of Medicine is located on the University's Health Sciences Campus in the Lake Nona neighborhood of Orlando.

[6] In the future, the campus is slated to house the UCF's College of Nursing allied health professions programs and a teaching hospital.

Background checks on applicants are required by the Association of Medical Colleges in order to prevent individuals with convictions for serious crimes from matriculating.

[10] Full accreditation has been granted to the medical school, and the college has accepted applications for the fifth class of 120 students for Fall 2013 enrollment.

The four-year medical program capitalizes on UCF's existing strengths in biomedical sciences, modeling and simulation.

[14] Since 2010, the Harriet F. Ginsburg Health Sciences Library has deployed iPads to incoming medical students during their orientation week in August.

The library is located on the second floor of the College of Medicine Medical Education building at the Lake Nona UCF Health Sciences Campus.

[21] In keeping with their goal of becoming 100% electronic, the Harriet F. Ginsburg Health Sciences Library has become the center of the College of Medicine’s iPad Initiative and deployment.