In 1924, the school relocated to a new campus at Ninth Avenue and Colorado Boulevard in Denver[2] on land donated by Frederick G. Bonfils.

The Medical Scientist Training Program (MSTP) awards both MD and PhD degrees.

[7] There are about 650 MD students at the school, plus 350 in the Physician Assistant and Physical Therapy programs and 400 in Graduate Medical Education.

Children's Hospital Colorado is routinely ranked in the top 10 in the country by the same publication.

[14] Major accomplishments include developing the international standard for classifying and numbering human chromosomes by Theodore Puck, the first successful human liver transplant by Thomas Starzl, the first description of toxic shock syndrome by James K. Todd,[15] the first description of ARDS, and the discovery of the T-cell receptor.

Other significant affiliates include National Jewish Health and Saint Joseph Hospital.

The school also operates physical therapy, physician assistant, and other degree programs which enroll several hundred more students.