It has become the largest educational institution in Eastern Latvia and is a member of the European University Association and EU²S², the European Union association of universities of small member states.

On 1 March 2018 the Daugavpils Medical College (lv) was integrated into the university as an autonomous institution.

A large Russian-speaking enrollment and faculty facilitates cooperation with universities outside of the European Union in the CIS.

Students can use Erasmus+ mobility options to study for one or two semesters at European partner universities.

Students are able to receive funding from the Else Marie Tschermak Foundation in Denmark to study or conduct research abroad.