It currently consists of eight departments which deal mainly with social, political, economic sciences and Information Technology.

[11] The language of instruction is Greek, although there are programs in foreign languages,courses both for international and local students, carried out in English, French, German, Italian, Turkish, Russian, Serbian, Bulgarian, Georgian, Albanian, Hebrew, Romanian and Arabic.

In 1954 the first Council of the Graduate School of Industrial Studies of Thessaloniki is established under the Ministerial Decree 70139/15-1-1954 of the minister Director- General of Northern Greece.

In 1956 the "Internal Rules of Procedure of the Graduate School of Industrial Studies of Thessaloniki" got approved.

Until the issuance of the Royal Decrees provided for by the relevant Decree-Law, the School is temporarily governed by a five-member Senate.

It is made up of a group of buildings with a total area of approximately 40,000 m2, consisting of amphitheaters, teaching and seminar rooms, offices and the areas of the administration sections, a restaurant (which operates during the whole academic year), a library, a basketball court, a gymnasium and a book-store; also a child-care station will soon be operating.

[25] It includes study areas, public computers running Linux and Windows[26] and photocopy machines.

[29][30] The University of Macedonia is a good business school with strong regional influence according to Eduniversal, it has received 2 palmes of excellence by the ranking agency.

[32] An external evaluation of all academic departments in Greek universities was conducted by the Hellenic Quality Assurance and Accreditation Agency (HQAA).

[44][45][46] According to the university's tradition, caps and gowns are worn only by members of faculty at graduation ceremonies.

The university also has an environmental student team doing various activities on and off campus, such as tree and flower planting.

The university hosts an active and influential Open Source Team that has made significant contributions to the field.

Among their notable achievements is the development of the application my.uom.gr (github code), which serves as a vital resource for the university community.

In recognition of their impactful work, the open source team received the "Influential Congress of the Year[48]" award from the Thessaloniki Convention Bureau.