On 13 November 1883, the School Board assented to use of the Central Collegiate Institute (26 Isabel Street) for the Medical College.

On the evening of Thursday, 15 November 1883, James Kerr, the first Dean of Medicine, delivered his inaugural address to the School:This fact, I think, is somewhat characteristic of the country in which we live and its extraordinary progressive tendencies, for I believe it to be the first time in the history of medicine that the student requested that he should be supplied with teachers, instead of teachers soliciting the students to be taught.A week later, the first lecture at the college was given by Dr. R. J.

[3][9] In 1892, the Manitoba Medical College saw its first female graduate, Hattie Foxton, who passed her exams with first-class standing for Doctor of Medicine and Master of Surgery.

[3] In 1897, the Bacteriological Research Building of the Manitoba Medical College was designed by architect Charles Henry Wheeler.

[12] In 1900, the University of Manitoba Act allowed the U of M to do its own teaching and appoint full-time professors to the Medical College, which it did in 1904 (bacteriologist, physiologist, botanist, and physicist).

[8] In 1932, the college adopted an official quota system to reduce the number of Jews entering the medical profession.

[14] In 1955, a building was built to house the library, microbiology, and cafeteria wing of the Manitoba Medical College, and opened the following year.

Part of the Memorial reads, "In enduring remembrance of the Graduates and students of this school who laid down their lives in Wars of the Empire, their names are here inscribed by the Manitoba Medical Alumni Association.... To you from falling hands we throw the torch.

[4][5] Each department is involved in teaching, research, service and clinical activities with an academic staff of approximately 1,630 faculty members.