[1] St. Boniface Hospital is a tertiary health care facility,[2] employing nearly 3,500 staff and 340 doctors with admitting privileges.

[7] The hospital's primary research mandate is in cardiovascular studies, imaging (especially MRI), neurodegenerative disorders, and nutraceuticals.

[23] Basic medical care is a benefit provided to all Canadians through Canada's publicly funded health system.

[24] However, significant additional funding is required for medical research, improvements in patient services, and the clinical programs found at St. Boniface Hospital.

It comprises three separate units: the G. Campbell MacLean Building, the Dr. Andrei Sakharov MRI Centre, and the I. H. Asper Clinical Research Institute, which are operated with research grants, industry contracts, fundraising, and funding from the University of Manitoba.

[28] Its primary research mandate addresses three main areas: cardiovascular sciences, magnetic resonance imaging (MRI) and spectroscopy, and degenerative disorders associated with aging.

In addition, the Centre undertakes research in anesthesia, epidemiology, family medicine, infectious diseases, nephrology, nursing, nutraceuticals, pharmaceuticals, sleep disorders, and surgery.

[29] St. Boniface Hospital's Institute of Cardiovascular Sciences researches heart disease at the cellular and molecular levels.

[35] The DND is a neurodegenerative research team working to identify causes and treatments for disorders like Alzheimer’s, strokes, traumatic brain injury, and central nervous system degeneration, to study the effect of diabetes on neurodegeneration, and to conduct sleep studies.

[39] CCARM’s mandate is to research natural health products and give the results to the scientific community and the general public.

[43] The facility allows radiologists to diagnose abnormalities of the brain, spinal cord, internal organs and joints.

[49] St. Boniface Hospital is affiliated with the University of Manitoba's education and research branches, providing internship and practicum positions for students.

[52] The hospital works with multiple University of Manitoba faculties, including medicine, nursing, pharmacy, social work, respiratory therapy, physiotherapy and occupational therapy, as well as with Red River College and Collège universitaire de Saint-Boniface.

[52] St. Boniface Hospital also hosts the Winnipeg Critical Care Nursing Education Program.

[2][54] Patients are referred to the hospital by their doctors or clinics for specialized care, though most are admitted through the emergency department.

[63] The Mental Health program provides psychological and counselling services to adult and adolescent patients.

[68] It provides: angiography, bone density imaging, CT scans, MRIs, mammography, nuclear medicine tests, ultrasounds and X-rays.

[70] They run tests in biochemistry, hematology, immunology, microbiology, cytology and pathology for patients and doctors in Manitoba.

[71] St. Boniface Hospital provides acute and chronic hemodialysis as part of the Manitoba Renal Program.

[76] According to internal reviews, the hospital reduced average wait times for acute care surgical patients from 10 hours to 3 between October 2008 and February 2009.