The West Bank campus was previously Saint Mary's Hospital and Fairview-Riverside Medical Center.

Areas of specialization includes organ and blood and marrow transplantation, neurosciences, pediatrics and behavioral illnesses.

Masonic Children's Hospital is also a state designated Level III Trauma Center.

Fairview agreed to spin off the University hospital in 2023, but as of March 18 it was uncertain whether it would be a charitable gift or a sale [14]

The world's first open heart surgery and the first bone marrow transplant were done at the University of Minnesota Medical Center.