[5] At the hospital, John Lewis, Walton Lillehei, Richard Varco, and others performed open-heart surgery in 1952.

[6] The first portable cardiac pacemaker was created by Earl Bakken with the help of Walton Lillehei and Richard Varco in 1957.

The University of Minnesota Medical School is part of the Academic Health Centers (AHC) in the United States.

[15] The Medical School also offers 10 pathways for students to experience longitudinal integrated clerkships at hosting sites, each with a different focus.

The Duluth campus, formerly the University of Minnesota Duluth School of Medicine, has approximately 65 students enrolled for each of the first two years of medical school as of 2022, after which they transfer to the Twin Cities campus for their clinical rotations.

[18][better source needed] Duluth is also a primary site for the Center for American Indian and Minority Health.

[19][better source needed] Research conducted by Sylvain Lesné in the area of Alzheimer's disease was investigated after a Science magazine article reported some allegations that the images in the paper were manipulated in a 2006 Nature publication, co-authored by Lesné, Karen Ashe, and others.