It was founded in 2004 following the reform of the university higher education system and is organized in 5 Faculties, 2 graduate schools and 9 institutes.

[4] The establishment is located on Tahar-Haddad Avenue in Monastir, near the Higher Institute of Biotechnology, the Faculty of Dentistry and that of Pharmacy.

[10][11] It includes sixteen university establishments (five faculties, two schools and nine institutes) distributed between the governorates of Monastir and Mahdia.

[12] The University of Monastir is an active institution in the fields of pharmaceutical studies and dental surgery, as well as design and fashion.

[15] The university represents the third research pole in Tunisia with its accredited research structures: Scientific production is increasing starting from the year 2009 and reached 1,469 publications in 2014 in the form of doctoral theses, master's theses, indexed and non-indexed publications, patents and joint supervision supported.