[3] The college has been located in Manchester's historic Amoskeag Millyard since 2001, originally at a site on Commercial Street and, since 2015, at the Pandora Mills complex.

The campus also has an articulation agreement with the Massachusetts College of Pharmacy and Health Sciences that allows students to dual enroll in the pre-pharmacy or physician assistant programs offered at the latter's Manchester location.

UNHM has also established a partnership with the Institute at Palazzo Rucellai in Florence, Italy, which allows students in the former's Politics and Society program to study abroad.

[12] In 2022, Money.com ranked UNH Manchester #204 out of all colleges and universities in the United States in an assessment of educational quality, affordability, and career outcomes.

Located at 1000 Elm Street, UNH Downtown Commons offers double and triple rooms, on-site dining, laundry facilities, and other amenities.

UNH Manchester also partners with the New Hampshire Institute of Art to offer meals in the NHIA dining hall, located on Spring Street.

Manchester is home to the New Hampshire Fisher Cats, the Double-A affiliate of Major League Baseball's Toronto Blue Jays.

The Fisher Cats play home games at Northeast Delta Dental Stadium, a 7,722-seat venue approximately a half-mile from UNH Manchester.

The University of New Hampshire's Manchester campus connects the research and knowledge of students, faculty, and staff with the local community through public programs and events.

Through the Bureau, campus faculty and students share, free of charge, their disciplinary expertise and research experience in the STEM fields, the social sciences, and the humanities.