Also part of the major clinical facilities is the Oklahoma City VA Medical Center.

In 1910, OU's fledgling two-year medical school moved to Oklahoma City and became a four-year program.

The College of Pharmacy, OU's oldest professional program, made the move from Norman to Oklahoma City five years later.

[5] On July 1, 1993, the University Hospital system officially became independent of the State of Oklahoma Department of Health Services.

UHAT and community leaders founded the nonprofit, OU Medicine, which executed a $750 million buyout of HCA Healthcare's management agreement and ownership stake of its hospital facilities in 2018.