Later on, under the administration of Enrique A. Jiménez, the government purchased around 60 hectares of land in the neighborhood of El Cangrejo, which would eventually become the university's main campus.

Construction began in January 1948 under the supervision of Alberto De Saint Malo, who was the Dean of the Engineering and Architecture Faculty at the time.

In the 1950s, construction continued and 11 additional buildings were built, which would hold the Biochemistry Center, and the Faculties of Pharmacy, and Public Administration and Commerce.

Between 1970 and 1980, the buildings that were used for Biology, Architecture, Engineering, Humanities (other), the Simón Bolivar Library and Laboratory of Specialized Analysis were finished.

Professors in areas of science and technology, medical health, economics and law have been invited to give keynotes and also teach in other campuses around the world.