[2][3] The university's central administrative and academic building, located on the seaport seafront, it is often referred to as the main campus, but actually the university does not have a single main site, as it has multi sites with buildings being geographically distributed within the wider region of Volos across the city districts.

[4][5] The emblem of the University of Thessaly is Chiron, who used to live in Pelion Mountain and was famous for his special knowledge about medicine, music, archery, hunting, gymnastics and the art of prophecy.

This was followed in 2019 by the Technological Educational Institute of Central Greece (TEICG) main campus (2013–2019)[2] in the City of Lamia and its Departments of Nursing, Physiotherapy, Computer Science, Electronic Engineering, they also are merging with University of Thessaly.

University of Thessaly owns a small Student Residence Hall in Volos with a capacity of 40 rooms.

It offers short-term courses on-campus and by Distance e-Learning Mode off-campus mediated via in real time computer-mediated communication, certified by the EOPPEP - National Organization for the Certification of Qualifications and Vocational Guidance (Greek: Εθνικός Οργανισμός Πιστοποίησης Προσόντων και Επαγγελματικού Προσανατολισμού - Ε.Ο.Π.Π.Ε.Π.).

[4][5] An external evaluation of all academic departments in Greek universities was conducted by the Hellenic Quality Assurance and Accreditation Agency (HQA) in the previous years.