In June 1954, a new campus was opened on a 4.86-hectare (12.0-acre) lot along Samson Road, Caloocan, then it was known as UE Tech.

With the Technical School as a junior college offering liberal arts courses and training technical subjects, and a complete secondary course with both academic and vocational curricula, this brought the university into compliance with the 2-2 Plan of the Department of Education.

School year 1957–1958 marked the offering of general courses leading to the Associate of Arts, Bachelor of Arts and Bachelor of Business Administration degrees and a one-year course leading to a Certificate in Secretarial Science.

Thus, began the campus shift from being a vocational-technical school to becoming an academic extension of UE Manila.

The school used to be in what was then the College of Dentistry building on Aurora Boulevard across from the UE Ramon Magsaysay Memorial Medical Center.

In 1977, Dean Oscar Limlingan of the College of Engineering was appointed officer-in-charge of UE Caloocan.

This six-storey edifice, which cost nearly 300 million pesos to build, has 54 air-conditioned classrooms, multimedia rooms, computer laboratories, a Gigabit Ethernet system, a parking area, the Benjamin G. Chua Jr. Library (in honor of the UE trustee with the same name), an information kiosk with info-retrieval machines, deans offices, faculty rooms, college offices, student council offices, two elevators, a cafeteria and a helipad.

Dr. Lucio C. Tan Building is a ten-story building and the new home of UE Caloocan's Elementary and High School Department or EHSD (Currently known as Basic Education Department or BED) kindergarten and elementary pupils and high school students.

The edifice, named after UE's chairman of the board and chief executive officer, features modern classrooms and laboratories, a 500-seat multipurpose hall, a spacious library complete with multi-media facilities, and many more.

This office takes charge of monitoring, evaluating and implementing the community involvement of students and faculty members on both campuses.

It maintains close linkage with law enforcement agencies off-campus, to attain the rationale objectives the office was created for.