The college is composed of eight institutes, two inter-programs and three affiliated units.

Scientia (Latin for science) is the official student publication of the college.

It is the only student college publication which has its own office located at the basement of the CSLib Building.

As of 2016, the Commission on Higher Education of the Philippines has identified 23 centers of excellence (COEs) in U.P.

The COEs in the college are Biology, Chemistry, Geology, Marine Science, Environmental Science, Mathematics, Molecular Biology & Biotechnology (MBB) and Physics.