[2] Initially the facility was placed under the jurisdiction of the University of the Philippines (UP) Diliman's Office of the President as per the approval of the UP Board of Regents in its July 31, 2009 meeting.

From January 2013 until the opening of its building on September 11, 2019,[4] it was temporarily housed at the National Institute of Molecular Biology and Biotechnology at UP Diliman To make DNA sequencing and bioinformatics services accessible to Filipino researchers, the DNA Sequencing Core Facility (DSCF) and Core Facility for Bioinformatics (CFB) were established with funding support from the DOST.

In January 2020, the PGC in collaboration with UP Manila National Institutes of Health developed an RT-PCR SARS CoV-2 detection kit.

Genomic studies in the field of agriculture, biodiversity, forensics, health, and ethnicity are conducted in the DSCF with the intent to specifically cater to Filipino needs.

It is also augmented by an IBM Blue Gene supercomputer which is also used by the Philippine Atmospheric, Geophysical and Astronomical Services Administration (PAGASA) and Project Nationwide Operational Assessment of Hazards (Project NOAH) for weather forecast and climate change modelling purposes in addition to genomic research use.