[3][4] Page 436 of the book The Essential Wonder Woman Encyclopedia (2015) by Phil Jimenez and John Wells (under the entry "Wallis, Angelica" in the "W" section) designated the Amalgam Universe as Earth-496 in the DC Multiverse.

The issues were all presented as if the "company" had existed for decades, with stories and editorial comments referring to a fictional history stretching back to the Golden Age of Comic Books, including retcons and reboots; for example, they referred to Secret Crisis of the Infinity Hour (an amalgamation of Marvel's Marvel Super Heroes Secret Wars, DC's Crisis on Infinite Earths, Marvel's The Infinity Gauntlet, and DC's Zero Hour: Crisis in Time!, respectively), which featured the well-known cover of Crisis on Infinite Earths #7, but with Super-Soldier holding the dead body of his teenage sidekick the American Girl (an amalgamation of DC's Supergirl and Marvel's Carol Danvers and James Buchanan "Bucky" Barnes)[7] instead of Superman holding the dead body of Supergirl.

Nineteen of the 24 issues included phony letter columns to provide the illusion of background to the stories, with the fans' hometowns formed by amalgamating the names of existing American cities.

To prevent the Brothers from destroying each other, characters from each universe battled to determine which universe would survive (a real world vote by readers of the series was conducted to determine the outcome of five of the in-comic battles, with three of them favoring the Marvel hero).

Access, a new character created specifically for the event and co-owned by both DC and Marvel, served as a gatekeeper who became stuck while traveling between the two universes.

Batman, Captain America and Access were thus able to make the Brothers realize that their conflict was pointless and the two universes were separated once again.