It lies in the German federal states of Lower Saxony, Hesse and North Rhine-Westphalia.
In the south the Upper Weser Valley crosses the Solling-Vogler Nature Park and, in the north, the Weser Uplands Schaumburg-Hamelin Nature Park.
The Upper Weser Valley is bordered by the following uplands (from south to north): Left-hand side: Right-hand side: The towns of the Upper Weser Valley are Hann.
The Upper Weser Valley has is agriculturally and culturally important.
The valley is crossed by several railway lines at places like Hann.