Important towns of this region include Bad Karlshafen, Holzminden, Höxter, Bodenwerder, Hameln, Rinteln, and Vlotho.
In its narrowest sense, the following would be included (running from north to south): The largest contiguous area of forest in the Weser Uplands lies on the Solling in the Solling-Vogler Nature Park.
The picturesque landscape of the Weser Uplands has inspired many landscape painters and artists: Jacob Pins (1917–2005), Robert Batty, Christian Andreas Besemann, Carl Ferdinand Fabritius, Robert Geißler, Wolfgang Heinrich, Karl Arthur Held, Alfred Hesse, Rudolf Jahns, Herbert Mager, Anton Wilhelm Strack (1758–1829), Pascha Johann Friedrich Weitsch and August Wenderoth.
Other notable attractions are the Schillat Cave, the Tonenburg in Höxter-Albaxen, the Neuhaus Wildlife Park, the Weserstein in Hann.
Large areas are also utilized by agriculture and forestry and firms involved in processing the products of these industries, such as sawmills.