The university hospital as such was founded in 1708 as the first clinic with the specific intention of facilitating the practical education of medical students.

The building (the former residence of the President of the Royal Chancellery Bengt Gabrielsson Oxenstierna) today houses the Uppsala University Faculty of Law.

The present Akademiska sjukhuset was established in 1850 as an organizational merger of the county hospital and the university clinic, and a new building was inaugurated in 1867 on the hill below Uppsala Castle to the southeast.

In 1663 medical professor and amateur architect Olaus Rudbeck designed the anatomical theatre located in the Gustavianum, which at the time served as the main building of Uppsala University.

The helicopter is crewed by two IFR licensed pilots, with medical personnel consisting of a doctor and a nurse both specializing in intensive care and anesthesia.

[12] In addition to the short range mobile intensive care provided by the helicopter, Uppsala University Hospital owns a Bombardier Learjet 45.

The aircraft is equipped by LifePort and capable of providing long range intensive care transports of up to two patients on stretchers or in incubators.