Upton is a spring line village and civil parish at the foot of the Berkshire Downs, about 2 miles (3 km) south of Didcot in the Vale of the White Horse district.

[2] Shortly after the Domesday Book was completed in 1086 Upton became the property of Wynebald de Ballon who in 1092 granted a moiety of the manor to the Cluniac Bermondsey Abbey.

The Domesday Book of 1086 lists Optone as having a "church",[3] but at that time both Upton and Aston Upthorpe were chapelries within the ecclesiastical parish of Blewbury.

[2] The Didcot, Newbury and Southampton Railway through the parish was completed in 1881, and a station to serve Upton and neighbouring Blewbury was opened in 1883.

The former Upton and Blewbury station building survives as a private house, and part of the line is now used as a pedestrian and cycle path.