Uptown is a section of Harrisburg, Pennsylvania located North of the Midtown and Downtown neighborhoods.

After being devastated in 1972 by the flooding of Hurricane Agnes, the neighborhood slipped into a moderate decline.

Since then, new homeowners have made improvements, causing property values to increase dramatically through the beginning of the 21st century.

With the Susquehanna River's Riverfront Park and Capital Area Greenbelt within walking distance—as well as Italian Lake—Uptown Harrisburg is an example of relaxed urban living.

Much of Uptown's development (post-automobile) lends itself to having longer blocks, rear alleys with detached garages, and shopping plazas/large surface parking lots.