Returning to Italy, he climbed Mount Etna twice to study the crater, which Pietro Bembo references in his dialogue De Aetna.
He was follower of Constantine Lascaris at Messina, friend of Pietro Bembo, and collaborator of Aldo Manuzio,[2] for whose circle he published a grammar of Ancient Greek in 1498.
In 1484 Urbano moved to Florence at the invitation of Lorenzo de' Medici who appointed him tutor of his son Giovanni, the future Pope Leo X.
He died in 1525 aged 81 years, as recorded by Pierio Valeriano on his tombstone in the wall of the Basilica Santa Maria Gloriosa dei Frari in Venice.
[3] Bolzanio's most important work is Institutiones Graecae Grammatices, a grammar of Ancient Greek published for the ciricle of Aldo Manuzio and dedicated to Giovanni Francesco Pico della Mirandola.