After all matches in both series were played, a one-round final was held between the two best performing teams in each group,[5] which were Cooper and Paso de la Arena.

Since no promotion system was yet implemented, they would have to play the following season in the same division another time; though them and Paso de la Arena would be granted two spots for the 2022 Copa Uruguay, being sorted into the Preliminary and First Round respectively.

[7] The league would welcome several new teams, those being Academia, Deportivo C.E.M., Estudiantes del Plata and Lito, though its format would not be altered.

Additionally, a promotion spot to the Uruguayan Primera División Amateur would be implemented for the 2022 season, with it being won by title-holders Cooper after beating Lito, who had just returned to the league system, on penalties (3-4).

[8] No relegation from the Primera División Amateur to the Primera "D" would be implemented yet, though; and the team who finished last in the league would be deaffiliated - that spot would go to Keguay, as though they beat Hacele a la Vida on a relegation playoff, the result would ultimately be invalidated due to them unproperly fielding unregistered players.