Ust-Mosikha (Russian: Усть-Мосиха) is a rural locality (a selo) and the administrative center of Ust-Mosikhinsky Selsoviet, Rebrikhinsky District, Altai Krai, Russia.

Ust-Mosikha is located 31 km northwest of Rebrikha (the district's administrative centre) by road.

Makarovo is the nearest rural locality.

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