According to the 2002 Tanzania National Census, the population of the Uyui District was 281,101.

[1] The district includes the Mbola cluster of Millennium villages.

[2] According to the 2012 Tanzania National Census, the population of Uyui District was 396,623.

[4] Unpaved Trunk road T18 from Singida Region to Kigoma and unpaved trunk road T8 from Mbeya to Mwanza pass through the district.

[5] The Tanzanian Central Line train - from Dar es Salaam to Kigoma - passes through the district.