Víctor Casco de Mendoza (c. 1560-1600s) was a Spanish nobleman.

He held political posts during the Viceroyalty of Peru, serving as alcalde, regidor and lieutenant governor of Buenos Aires[1] and Asuncion.

[2] He was born in Asuncion, the son of Gonzalo Casco, a Spanish conquistador, born in Asturias, and María de Mendoza Irala, belonging to a noble family of Asuncion.

He was married to Luisa de Valderrama, daughter of Juan de Fustes and Beatriz Ramírez.

[3] Víctor Casco de Mendoza was one of the sixty-three neighbors who accompanied Juan de Garay in the second foundation of Buenos Aires.