During World War II the squadron saw extensive action throughout the Pacific Theater of Operations especially at the Battle of Guadalcanal as part of the Cactus Air Force.

Deploying shortly after to Henderson Field on Guadalcanal in the Solomon Islands in their Grumman F4F Wildcats, the Wolfpack joined the Cactus Air Force with Marine Aircraft Group 11.

On 31 January 1943 Jefferson J. DeBlanc downed five enemy aircraft in a single mission, and was awarded the Medal of Honor for this action.

In recognition of its valor and its contributions to victory during its service on Guadalcanal, VMF-112 was awarded the Presidential Unit Citation (US) for 7 August – 9 December 1942.

VMF-112 was reactivated with the Corsair, but eventually flew the Grumman F9F Panther, the North American AF-1E Fury, and Vought F8U-1 Crusader.

VMFA-112 moved to NAS Fort Worth Joint Reserve Base (JRB) in September 1996 and continues to operate there.

The conceptual program would allow an F/A-18A+ to land on a hastily constructed runway and refuel and rearm quickly without having to return to base, as is the current operating procedure.