The team was founded in 2014 by Rossi to promote young Italian talent in Grand Prix racing.

Beginning in 2022, the VR46 team entered the MotoGP championship in their own right, taking over the grid slots from Esponsorama Racing who left the premier class after 10 seasons.

[3] In 2023, Bezzecchi managed to fight for the championship until late in the season where injuries and an older bike derail his title run.

For 2024 Luca Marini depart the team to join HRC Repsol Honda[4] and will be replaced by Fabio Di Giannantonio.

[11] VR46 Racing will also field an official Ducati Desmosedici on the track, currently assigned to rider Fabio Di Giannantonio until 2026.