In addition to its headquarters in Blacksburg, Virginia, United States, VTLS had five international offices in Australia, Brazil, India, Malaysia and Spain.

This forerunner of VTLS Classic and Virtua, consisting of an Online Public Access Catalog (OPAC) and an automated circulation system, was installed at Virginia Tech's Newman Library in September 1975.

In 2000, VTLS introduced support for radio-frequency identification (RFID) technology for circulation and security, later expanding it into the "Fastrac" product division.

Throughout its history, VTLS was a member of many industry organizations, including: American Library Association (ALA), Book Industry Study Group (BISG), Coalition for Networked Information (CNI), EDUCAUSE, International Federation of Library Associations and Institutions (IFLA), MARBI, National Information Standards Organization (NISO) for Z39.50, Online Computer Library Center (OCLC), the Unicode Consortium, and the Virginia Business Pipeline (VBP).

In June 2014, VTLS was purchased by Innovative Interfaces Inc., who continues to actively develop and support most of the VTLS-based software suites.